Antioxidants, Free Full-Text
Por um escritor misterioso
Last updated 23 maio 2024
Age-related macular degeneration (AMD) is a complex, progressive degenerative retinal disease. Retinal pigment epithelial (RPE) cells play an important role in the immune defense of the eye and their dysfunction leads to the progressive irreversible degeneration of photoreceptors. Genetic factors, chronic inflammation, and oxidative stress have been implicated in AMD pathogenesis. Oxidative stress causes RPE injury, resulting in a chronic inflammatory response and cell death. The Y402H polymorphism in the complement factor H (CFH) protein is an important risk factor for AMD. However, the functional significance of CFH Y402H polymorphism remains unclear. In the present study, we investigated the role of CFH in the pro-inflammatory response using an in vitro model of oxidative stress in the RPE with the at-risk CFH Y402H variant. ARPE-19 cells with the at-risk CFH Y402H variant were highly susceptible to damage caused by oxidative stress, with increased levels of inflammatory mediators and pro-apoptotic factors that lead to cell death. Pretreatment of the ARPE-19 cell cultures with exogenous CFH prior to the induction of oxidative stress prevented damage and cell death. This protective effect may be related to the negative regulation of pro-inflammatory cytokines. CFH contributes to cell homeostasis and is required to modulate the pro-inflammatory cytokine response under oxidative stress in the ARPE-19 cells with the at-risk CFH Y402H variant.
Vitamin C: An Antioxidant Agent
Antioxidants are chemicals that block the activity of other
FACTSHEET: Free radicals, antioxidants and medical myths - Africa
Free radicals, antioxidants, and nutrition - ScienceDirect
Free Radicals and Antioxidants – Doris Day MD
ACS Symposium Series (ACS Publications)
Free Radicals: What You Need to Know
PDF) In vitro antioxidant and free radical scavenging activity of
Antioxidants for the Prevention and Treatment of Non-communicable
Recomendado para você
-
Arras io — Play for free at23 maio 2024
-
ARRAS.IO SHOW 6 BETA TANK IDEAS - TANK IDEAS #523 maio 2024
-
ARRAS.IO WIN DOMINATION MODE WITH TWIN & TEAM - 2 TEAMS MAZE DOMINATION23 maio 2024
-
arras io moments (by me) : r/Arrasio23 maio 2024
-
diep io arena closer 3D Models to Print - yeggi23 maio 2024
-
Review of Gravimetric Sensing of Volatile Organic Compounds23 maio 2024
-
Comparing RADseq and microsatellites for estimating genetic diversity and relatedness — Implications for brown trout conservation - Lemopoulos - 2019 - Ecology and Evolution - Wiley Online Library23 maio 2024
-
ARRAS.IO SHOW SUPER POWERFUL BETA BOSSES AUTO TIER - (CODE BY ME & FANMADE)23 maio 2024
-
MicroRNAs in Gametes and Preimplantation Embryos: Clinical Implications - ScienceDirect23 maio 2024
-
c++ - what does levelWeights mean in opencv detectMultiScale3? - Stack Overflow23 maio 2024
você pode gostar
-
Charlie Day's Wife Mary Elizabeth Ellis: How They Met, Kids - Parade23 maio 2024
-
Evan Parke, Detroit: Become Human Wiki23 maio 2024
-
💧 Showcasing the DIVINE SHINY BLOODLUST!23 maio 2024
-
WE'RE NOT REALLY STRANGERS Card Game - Fun Family Party Games for Adults Teens & Kids Game Night, Interactive Adult Card Game and Icebreaker, Ages 12+, 2-6 Players : Everything Else23 maio 2024
-
Cetacean stranding - Wikipedia23 maio 2024
-
Action Figure - Akuma no mi (Mero Mero no mi)- One Piece23 maio 2024
-
Getting Over It with Bennett Foddy, CoryxKenshin Wiki23 maio 2024
-
Stranger Things Chapter One: The Vanishing of Will Byers (TV Episode 2016) - IMDb23 maio 2024
-
Livro de Passatempos Sukodu Jogo de Números + 1500 Jogos - Coquetel - Contos e Crônicas - Magazine Luiza23 maio 2024
-
p16-sign.tiktokcdn-us.com/tos-useast8-p-0068-tx2/o23 maio 2024